A new print ad in Japan shows Chris Redfield kneeling in front of the
tombstone of one of Resident Evil's main characters. Whether this
means that the character is actually dead or this is just an
indication of a motivating factor in the story is unknown at this
time.
Speaking of Resident Evil 5 - has anyone tried the Japanese demo?
http://kotaku.com/5108033/resident-evil-suffers-a-death-in-the-family