DNAssist provides
an intuitive, single interface within which sequence files are
displayed, edited and analyzed. Several editor windows may be open,
and the user can work in any one of these windows by simply bringing
it to the top. The editor window is similar to a word processor
window, and sequences can be entered from the keyboard, selected
with the mouse pointer, copied, cut and pasted to and from the
clipboard, drag-and-dropped within the same or to other editor
windows, and text searches performed. The windows can also be
cascaded, tiled or minimized. The user can customize the display in
editor windows by selecting the font, font size, and line length. A
sequence is analyzed by simply bringing an editor window to the top,
and selecting the required analysis from the menu. All analyses can
also be performed on a selected region of the sequence in an editor
window. Right clicking the mouse will provide a context-sensitive
popup menu. This gives the user a convenient shortcut to most menu
items. DNAssist also provides a Speedbar with buttons
representing common actions. The analyses available on
DNAssist include:
The conversion of a DNA sequence between the circular and
linear forms
The conversion of DNA to a RNA or a protein sequence
The conversion of RNA to a DNA or a protein sequence
Translating a DNA sequence to the amino acid sequence in one,
three or all six frames
Locating open reading frames (ORFs) in a DNA sequence
Locating specific sequence patterns in a sequence (this allows
wildcards, mismatches and gaps)
Performing a restriction enzyme analysis with a defined set of
enzymes
Performing a DNA promoter analysis with specified
transcription factors
Locating strong nucleosome positioning signals in DNA
Performing multiple alignments of DNA, RNA or proteins
Obtaining the molecular weight of a nucleic acid or protein
Obtaining the melting temperature of an oligonucleotide
Calculating the pI of a protein
Calculating the hydrophilic, hydrophobic or antigenic profile
of a protein
Obtaining the molar absorption coefficient and
E0.1% of a nucleic acid or a protein
Obtaining the nucleotide or amino acid composition of a
nucleic acid or protein
DNAssist brings all these
features together into one tightly integrated Windows®
application. This gives the user the freedom to work in the
intuitive IEAE of DNAssist like in a Word Processing
environment, and have an extensive and powerful battery of
analytical features a mouse click away.
The result of an
analysis is displayed in a result window and can be printed, saved
to disk or copied and pasted into third party applications. Saved or
copied results retain the format in which they were displayed. The
user can select from a wide range of formatting options. This
includes the display of sequences as continuous lines of text or as
text blocks. One or both strands of a DNA sequence can be displayed.
The position of the sequence numbers relative to the sequence can
also be specified, as can the font face and size. The user can also
specify the colors of boxes used to indicate identical or conserved
amino acids in multiple alignments. It is thus possible to customize
DNAssist to the preference of each user. The display
formatting options and the editor window options are saved to the
registry when the user exits DNAssist. In a multiple user
environment, these settings are associated with the name under which
the user logged onto Windows®. This allows many users to use
DNAssist on a single computer, where each user will have
customized preferences that are not changed by those of the other
users.
Microquant - The purpose of Microquant is to perform statistical analysis of results of biological assays and tests as described in the European Pharmacopoeia (Ph. Eur. 2000). Most parallel-line assays as for... ...
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